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Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Rattus norvegicus
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
CRRD ID: 69401
Description: Exhibits arachidonate-CoA ligase activity and long-chain fatty acid-CoA ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of insulin secretion. Localizes to mitochondrial membrane; neuronal cell body; and peroxisome. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid.
Type: protein-coding
Also known as: Acs4; arachidonate--CoA ligase; Facl4; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; LACS 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4
Homo sapiens (human) : ACSL4 (acyl-CoA synthetase long chain family member 4)  HGNC  Alliance
Mus musculus (house mouse) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Canis lupus familiaris (dog) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Sus scrofa (pig) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Chlorocebus sabaeus (African green monkey) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Heterocephalus glaber (naked mole-rat) : Acsl4 (acyl-CoA synthetase long chain family member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,596,239 - 113,659,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acsl4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69401
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.