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Gene: Acsl4 (acyl-CoA synthetase long-chain family member 4) Rattus norvegicus
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Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Description: Exhibits long-chain fatty acid-CoA ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and triglyceride biosynthetic process. Localizes to the mitochondrial membrane; neuronal cell body; and peroxisome. Colocalizes with the endoplasmic reticulum. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Acs4; arachidonate--CoA ligase; Facl4; fatty acid Coenzyme A ligase, long chain 4; fatty acid-Coenzyme A ligase long chain 4; fatty acid-Coenzyme A ligase, long chain 4; LACS 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X113,596,247 - 113,660,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X112,046,187 - 112,109,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,168,547 - 36,232,162 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X36,222,015 - 36,285,631 (+)NCBI
CeleraX105,356,949 - 105,420,560 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Acsl4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69401
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.