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Gene: Pclo (piccolo (presynaptic cytomatrix protein)) Rattus norvegicus
Symbol: Pclo
Name: piccolo (presynaptic cytomatrix protein)
CRRD ID: 69406
Description: Exhibits calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in presynaptic active zone assembly and regulation of ubiquitin protein ligase activity. Localizes to several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: aczonin; multidomain presynaptic cytomatrix protein Piccolo; presynaptic cytomatrix protein; protein piccolo
Homo sapiens (human) : PCLO (piccolo presynaptic cytomatrix protein)  HGNC  Alliance
Mus musculus (house mouse) : Pclo (piccolo (presynaptic cytomatrix protein))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pclo (piccolo presynaptic cytomatrix protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PCLO (piccolo presynaptic cytomatrix protein)
Canis lupus familiaris (dog) : PCLO (piccolo presynaptic cytomatrix protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pclo (piccolo presynaptic cytomatrix protein)
Sus scrofa (pig) : PCLO (piccolo presynaptic cytomatrix protein)
Chlorocebus sabaeus (African green monkey) : PCLO (piccolo presynaptic cytomatrix protein)
Heterocephalus glaber (naked mole-rat) : Pclo (piccolo presynaptic cytomatrix protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: This gene aligns across a gap in the Rnor_6.0 reference genome assembly, and therefore, the 5' end of this gene was annotated on NW_007905776.1 and the 3' end was annotated on NW_007905775.1 in NCBI's Rattus norvegicus Annotation Release 105. [15 Jun 2015]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0416,454,904 - 17,058,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl416,454,904 - 17,058,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0416,428,814 - 16,661,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0416,923,700 - 17,031,648 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4415,911,051 - 16,269,090 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1415,911,050 - 16,269,090 (-)NCBI
Celera415,219,539 - 15,569,109 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pclo
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69406
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.