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Gene: Pclo (piccolo (presynaptic cytomatrix protein)) Mus musculus
Symbol: Pclo
Name: piccolo (presynaptic cytomatrix protein)
Description: Exhibits profilin binding activity. Involved in several processes, including insulin secretion; presynapse to nucleus signaling pathway; and synaptic vesicle clustering. Localizes to postsynaptic density and presynaptic active zone cytoplasmic component. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acz; aczonin; brain-derived HLMN protein; mKIAA0559; multidomain presynaptic cytomatrix protein; Pico; protein piccolo
Homo sapiens (human) : PCLO (piccolo presynaptic cytomatrix protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pclo (piccolo (presynaptic cytomatrix protein))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pclo (piccolo presynaptic cytomatrix protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PCLO (piccolo presynaptic cytomatrix protein)
Canis lupus familiaris (dog) : PCLO (piccolo presynaptic cytomatrix protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pclo (piccolo presynaptic cytomatrix protein)
Sus scrofa (pig) : PCLO (piccolo presynaptic cytomatrix protein)
Chlorocebus sabaeus (African green monkey) : PCLO (piccolo presynaptic cytomatrix protein)
Heterocephalus glaber (naked mole-rat) : Pclo (piccolo presynaptic cytomatrix protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl514,514,918 - 14,863,459 (+)EnsemblGRCm38mm10GRCm38
GRCm38514,514,906 - 14,863,465 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37514,514,918 - 14,863,459 (+)NCBIGRCm37mm9NCBIm37
MGSCv36514,520,924 - 14,801,999 (+)NCBImm8
Celera1224,890,712 - 25,239,859 (+)NCBICelera
Cytogenetic Map5A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pclo
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69450
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.