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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Mus musculus
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Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein kinase binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; regulation of lipid metabolic process; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; membrane; and nucleus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADD-1; ADD1; adipocyte determination- and differentiation-dependent factor 1; bHLHd1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1c; sterol regulatory element binding factor 1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBImm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Srebf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69474
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.