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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Mus musculus
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein kinase binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; regulation of lipid metabolic process; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; membrane; and nucleus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADD-1; ADD1; adipocyte determination- and differentiation-dependent factor 1; bHLHd1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1c; sterol regulatory element binding factor 1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBImm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Srebf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69474
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.