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Gene: Synj1 (synaptojanin 1) Mus musculus
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Symbol: Synj1
Name: synaptojanin 1
Description: Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including dephosphorylation; regulation of postsynaptic neurotransmitter receptor internalization; and vesicle-mediated transport in synapse. Localizes to Schaffer collateral - CA1 synapse; glutamatergic synapse; and membrane coat. Predicted to colocalize with microtubule. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and early infantile epileptic encephalopathy 53. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Orthologous to human SYNJ1 (synaptojanin 1); PARTICIPATES IN altered clathrin-dependent synaptic vesicle endocytosis; clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 3,4-methylenedioxymethamphetamine; benzo[a]pyrene; ethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A930006D20Rik; AA675315; mKIAA0910; synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; synaptojanin-1
Orthologs:
Homo sapiens (human) : SYNJ1 (synaptojanin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Synj1 (synaptojanin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Synj1 (synaptojanin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SYNJ1 (synaptojanin 1)
Canis lupus familiaris (dog) : SYNJ1 (synaptojanin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Synj1 (synaptojanin 1)
Sus scrofa (pig) : SYNJ1 (synaptojanin 1)
Chlorocebus sabaeus (African green monkey) : SYNJ1 (synaptojanin 1)
Heterocephalus glaber (naked mole-rat) : Synj1 (synaptojanin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1690,936,092 - 91,011,308 (-)EnsemblGRCm38mm10GRCm38
GRCm381690,936,092 - 91,013,727 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371690,936,342 - 91,011,553 (-)NCBIGRCm37mm9NCBIm37
MGSCv361690,824,951 - 90,900,361 (-)NCBImm8
Celera1692,017,943 - 92,093,156 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Synj1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69492
Created: 2001-11-27
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.