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Gene: Serpine2 (serine (or cysteine) peptidase inhibitor, clade E, member 2) Mus musculus
Symbol: Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
CRRD ID: 70077
Description: Exhibits serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Localizes to extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; limb; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2); PARTICIPATES IN fibrinolysis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 2-chloroethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B230326M24Rik; GDN; glia-derived nexin; ne; P; PAI-1; peptidase inhibitor 7; PI-7; PI7; PN; PN-1; protease nexin 1; protease nexin I; S; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serine protease-inhibitor 4; serpin E2; Spi4
Homo sapiens (human) : SERPINE2 (serpin family E member 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Serpine2 (serpin family E member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine2 (serpin family E member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE2 (serpin family E member 2)
Canis lupus familiaris (dog) : SERPINE2 (serpin family E member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine2 (serpin family E member 2)
Sus scrofa (pig) : SERPINE2 (serpin family E member 2)
Chlorocebus sabaeus (African green monkey) : SERPINE2 (serpin family E member 2)
Heterocephalus glaber (naked mole-rat) : Serpine2 (serpin family E member 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl179,794,197 - 79,861,180 (-)EnsemblGRCm38mm10GRCm38
GRCm38179,794,317 - 79,858,665 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37179,790,896 - 79,855,240 (-)NCBIGRCm37mm9NCBIm37
MGSCv36179,673,221 - 79,737,660 (-)NCBImm8
Celera179,823,073 - 79,887,353 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Serpine2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70077
Created: 2002-01-22
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.