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Gene: BAX (BCL2 associated X, apoptosis regulator) Homo sapiens
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Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Description: Exhibits several functions, including BH3 domain binding activity; channel activity; and protein dimerization activity. Involved in several processes, including apoptotic mitochondrial changes; apoptotic signaling pathway; and positive regulation of apoptotic process. Localizes to several cellular components, including the BAK complex; BAX complex; and mitochondrial envelope. Colocalizes with the cell periphery. Implicated in ataxia telangiectasia; colon adenocarcinoma; and precursor lymphoblastic lymphoma/leukemia. Biomarker of several diseases, including Alzheimer's disease; cervical squamous cell carcinoma; osteoarthritis; prostate cancer (multiple); and teratoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4; BCL2-associated X protein omega; BCL2-associated X protein transcript variant delta2; bcl2-L-4; BCL2L4
Orthologs:
Mus musculus (house mouse) : Bax (BCL2-associated X protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bax (BCL2 associated X, apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bax (BCL2 associated X, apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : BAX (BCL2 associated X, apoptosis regulator)
Canis lupus familiaris (dog) : BAX (BCL2 associated X, apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bax (BCL2 associated X, apoptosis regulator)
Sus scrofa (pig) : BAX (BCL2 associated X, apoptosis regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,954,825 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,458,117 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBINCBI36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model