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Gene: Tgfb2 (transforming growth factor, beta 2) Rattus norvegicus
Symbol: Tgfb2
Name: transforming growth factor, beta 2
Description: Exhibits identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Localizes to several cellular components, including cell surface; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
Also known as: TGF beta 2 protein; TGF-B2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein
Homo sapiens (human) : TGFB2 (transforming growth factor beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Tgfb2 (transforming growth factor, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb2 (transforming growth factor beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB2 (transforming growth factor beta 2)
Canis lupus familiaris (dog) : TGFB2 (transforming growth factor beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb2 (transforming growth factor beta 2)
Sus scrofa (pig) : TGFB2 (transforming growth factor beta 2)
Chlorocebus sabaeus (African green monkey) : TGFB2 (transforming growth factor beta 2)
Heterocephalus glaber (naked mole-rat) : Tgfb2 (transforming growth factor beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tgfb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70491
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.