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Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Description: Exhibits ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including establishment of vesicle localization; positive regulation of cellular metabolic process; and regulation of intracellular signal transduction. Localizes to several cellular components, including dendrite cytoplasm; glutamatergic synapse; and perikaryon. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 3; malignant glioma; pancreatic adenocarcinoma; renal cell carcinoma; and small intestine adenocarcinoma. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
Homo sapiens (human) : MAP2K1 (mitogen-activated protein kinase kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Map2k1 (mitogen-activated protein kinase kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k1 (mitogen-activated protein kinase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Canis lupus familiaris (dog) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k1 (mitogen-activated protein kinase kinase 1)
Sus scrofa (pig) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Chlorocebus sabaeus (African green monkey) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Heterocephalus glaber (naked mole-rat) : Map2k1 (mitogen-activated protein kinase kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70495
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.