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Gene: Mapk14 (mitogen activated protein kinase 14) Rattus norvegicus
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Description: Exhibits ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in positive regulation of transcription by RNA polymerase II; protein phosphorylation; and response to glucose. Localizes to cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14); PARTICIPATES IN p38 MAPK signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: CRK1; Csaids binding protein; CSBP; Csbp1; Csbp2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; Exip; Hog; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; MGC105413; mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha; p38alpha Exip; p38Hog; Prkm14; Prkm15; reactive kinase; RK; Sapk2A; stress-activated protein kinase 2A
Homo sapiens (human) : MAPK14 (mitogen-activated protein kinase 14)  HGNC  Alliance
Mus musculus (house mouse) : Mapk14 (mitogen-activated protein kinase 14)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk14 (mitogen-activated protein kinase 14)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK14 (mitogen-activated protein kinase 14)
Canis lupus familiaris (dog) : MAPK14 (mitogen-activated protein kinase 14)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk14 (mitogen-activated protein kinase 14)
Sus scrofa (pig) : MAPK14 (mitogen-activated protein kinase 14)
Chlorocebus sabaeus (African green monkey) : MAPK14 (mitogen-activated protein kinase 14)
Heterocephalus glaber (naked mole-rat) : Mapk14 (mitogen-activated protein kinase 14)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Celera208,305,853 - 8,366,371 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mapk14
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70496
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.