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Gene: TP53 (tumor protein p53) Homo sapiens
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Symbol: TP53
Name: tumor protein p53
Description: Exhibits several functions, including enzyme binding activity; transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including intracellular signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including centrosome; nuclear lumen; and nuclear membrane. Colocalizes with nuclear body and transcription factor TFIID complex. Implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Biomarker of several diseases, including carcinoma (multiple); hematologic cancer (multiple); oral mucosa leukoplakia; oral submucous fibrosis; and serous cystadenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; FLJ92943; LFS1; mutant p53 protein; mutant tumor protein 53; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; truncated p53 protein; tumor protein 53; tumor suppressor p53; tumor suppressor TP53; tumor supressor p53
Orthologs:
Mus musculus (house mouse) : Trp53 (transformation related protein 53)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp53 (tumor protein p53)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53 (tumor protein p53)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53 (tumor protein p53)
Canis lupus familiaris (dog) : TP53 (tumor protein p53)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53 (tumor protein p53)
Sus scrofa (pig) : TP53 (tumor protein p53)
Chlorocebus sabaeus (African green monkey) : TP53 (tumor protein p53)
Heterocephalus glaber (naked mole-rat) : Tp53 (tumor protein p53)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl177,661,779 - 7,687,550 (-)EnsemblGRCh38hg38GRCh38
GRCh38177,668,402 - 7,687,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,571,720 - 7,590,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model