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Gene: Tert (telomerase reverse transcriptase) Mus musculus
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Symbol: Tert
Name: telomerase reverse transcriptase
Description: Exhibits telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in several processes, including positive regulation of glucose import; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Localizes to mitochondrion; plasma membrane; and telomerase catalytic core complex. Predicted to colocalize with PML body. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and vibrissa follicle. Orthologous to human TERT (telomerase reverse transcriptase); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4-hydroperoxycyclophosphamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EST2; MGC150124; TCS1; telomerase catalytic subunit; telomerase reverse transcriptase beta; TP2; TR; TRT
Orthologs:
Homo sapiens (human) : TERT (telomerase reverse transcriptase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tert (telomerase reverse transcriptase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tert (telomerase reverse transcriptase)
Pan paniscus (bonobo/pygmy chimpanzee) : TERT (telomerase reverse transcriptase)
Canis lupus familiaris (dog) : TERT (telomerase reverse transcriptase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tert (telomerase reverse transcriptase)
Sus scrofa (pig) : TERT (telomerase reverse transcriptase)
Chlorocebus sabaeus (African green monkey) : TERT (telomerase reverse transcriptase)
Heterocephalus glaber (naked mole-rat) : Tert (telomerase reverse transcriptase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1373,626,911 - 73,649,843 (+)EnsemblGRCm38mm10GRCm38
GRCm381373,626,911 - 73,649,843 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371373,764,449 - 73,786,489 (+)NCBIGRCm37mm9NCBIm37
MGSCv361374,093,003 - 74,115,043 (+)NCBImm8
Celera1375,955,877 - 75,977,918 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tert
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70505
Created: 2002-05-02
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.