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Gene: Fgd4 (FYVE, RhoGEF and PH domain containing 4) Rattus norvegicus
Symbol: Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Description: Exhibits actin filament binding activity. Involved in activation of JUN kinase activity and regulation of cell shape. Predicted to localize to the filopodium and lamellipodium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; acrylamide; ammonium chloride.
Type: protein-coding
Also known as: actin filament-binding protein frabin; actin-filament binding protein frabin; FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4
Homo sapiens (human) : FGD4 (FYVE, RhoGEF and PH domain containing 4)  HGNC  Alliance
Mus musculus (house mouse) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Canis lupus familiaris (dog) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Sus scrofa (pig) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01188,699,222 - 88,796,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,755,139 - 91,851,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,700,118 - 86,767,928 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,740,714 - 86,808,525 (-)NCBI
Celera1183,195,465 - 83,292,853 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fgd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 708357
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.