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Gene: Bhlhe41 (basic helix-loop-helix family, member e41) Rattus norvegicus
Symbol: Bhlhe41
Name: basic helix-loop-helix family, member e41
Description: Predicted to have several functions, including DNA-binding transcription factor binding activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in circadian rhythm and regulation of neuronal synaptic plasticity. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in sleep disorder. Orthologous to human BHLHE41 (basic helix-loop-helix family member e41); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: MODEL
Also known as: basic helix-loop-helix domain containing class B 3; basic helix-loop-helix domain containing, class B3; Bhlhb3; class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; enhancer-of-split and hairy-related protein 1; LOW QUALITY PROTEIN: class E basic helix-loop-helix protein 41; SHARP-1; Sharp1
Homo sapiens (human) : BHLHE41 (basic helix-loop-helix family member e41)  HGNC  Alliance
Mus musculus (house mouse) : Bhlhe41 (basic helix-loop-helix family, member e41)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bhlhe41 (basic helix-loop-helix family member e41)
Pan paniscus (bonobo/pygmy chimpanzee) : BHLHE41 (basic helix-loop-helix family member e41)
Canis lupus familiaris (dog) : BHLHE41 (basic helix-loop-helix family member e41)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bhlhe41 (basic helix-loop-helix family member e41)
Sus scrofa (pig) : BHLHE41 (basic helix-loop-helix family member e41)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04180,230,742 - 180,235,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,232,382 - 180,234,804 (-)Ensembl
Rnor_5.04244,394,139 - 244,398,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4167,334,944 - 167,338,512 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bhlhe41
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70900
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.