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Gene: Dll3 (delta like canonical Notch ligand 3) Rattus norvegicus
Symbol: Dll3
Name: delta like canonical Notch ligand 3
CRRD ID: 70953
Description: Exhibits Notch binding activity. Involved in central nervous system development; negative regulation of Notch signaling pathway; and regulation of neurogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL3 (delta like canonical Notch ligand 3); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving the main players; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: delta (Drosophila)-like 3; delta-like 3 (Drosophila); delta-like protein 3; delta3; drosophila Delta homolog 3
Homo sapiens (human) : DLL3 (delta like canonical Notch ligand 3)  HGNC  Alliance
Mus musculus (house mouse) : Dll3 (delta like canonical Notch ligand 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dll3 (delta like canonical Notch ligand 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLL3 (delta like canonical Notch ligand 3)
Canis lupus familiaris (dog) : DLL3 (delta like canonical Notch ligand 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dll3 (delta like canonical Notch ligand 3)
Sus scrofa (pig) : DLL3 (delta like canonical Notch ligand 3)
Chlorocebus sabaeus (African green monkey) : DLL3 (delta like canonical Notch ligand 3)
Heterocephalus glaber (naked mole-rat) : Dll3 (delta like canonical Notch ligand 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0185,485,875 - 85,493,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,485,289 - 85,493,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,697,034 - 86,704,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,373,482 - 83,381,219 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,451,593 - 83,459,330 (-)NCBI
Celera177,961,035 - 77,968,719 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dll3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70953
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.