Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) Rattus norvegicus
Analyze
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
Description: Exhibits several functions, including hydroxymethylglutaryl-CoA synthase activity; organic acid binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; cellular response to cholesterol; and cellular response to follicle-stimulating hormone stimulus. Localizes to the cytosol. Biomarker of obesity. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-(3-(trifluoromethyl)phenyl)piperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 1; hydroxymethylglutaryl-CoA synthase, cytoplasmic
Orthologs:
Homo sapiens (human) : HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Canis lupus familiaris (dog) : HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Sus scrofa (pig) : HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0252,427,351 - 52,445,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0270,791,035 - 70,809,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,737,090 - 51,754,583 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1251,665,322 - 51,682,816 (+)NCBI
Celera247,304,535 - 47,322,038 (+)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hmgcs1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70970
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.