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Gene: Hamp (hepcidin antimicrobial peptide) Rattus norvegicus
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Symbol: Hamp
Name: hepcidin antimicrobial peptide
Description: Predicted to have copper ion binding activity; hormone activity; and iron ion transmembrane transporter inhibitor activity. Involved in several processes, including cellular response to X-ray; cellular response to cytokine stimulus; and cellular response to lipid. Localizes to apical cortex; extracellular space; and intercalated disc. Used to study anemia and hepatocellular carcinoma. Biomarker of several diseases, including anemia (multiple); end stage renal disease; extrahepatic cholestasis; iron deficiency anemia; and liver disease (multiple). Human ortholog(s) of this gene implicated in hemochromatosis; hemochromatosis type 2B; and hepatocellular carcinoma. Orthologous to human HAMP (hepcidin antimicrobial peptide); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Hepc; hepcidin
Orthologs:
Homo sapiens (human) : HAMP (hepcidin antimicrobial peptide)  HGNC  Alliance
Mus musculus (house mouse) : Hamp (hepcidin antimicrobial peptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hamp (hepcidin antimicrobial peptide)
Pan paniscus (bonobo/pygmy chimpanzee) : HAMP (hepcidin antimicrobial peptide)
Canis lupus familiaris (dog) : HAMP (hepcidin antimicrobial peptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hamp (hepcidin antimicrobial peptide)
Sus scrofa (pig) : HAMP (hepcidin antimicrobial peptide)
Chlorocebus sabaeus (African green monkey) : HAMP (hepcidin antimicrobial peptide)
Heterocephalus glaber (naked mole-rat) : Hamp (hepcidin antimicrobial peptide)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0189,368,021 - 89,369,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,368,021 - 89,369,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,523,506 - 90,525,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,978,120 - 85,980,059 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,056,230 - 86,058,170 (-)NCBI
Celera180,539,771 - 80,541,710 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hamp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70971
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.