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Gene: Akap12 (A-kinase anchoring protein 12) Rattus norvegicus
Symbol: Akap12
Name: A-kinase anchoring protein 12
Description: Predicted to have adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of macromolecule metabolic process. Localizes to cytoplasm and neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A kinase anchoring protein 12 alpha; A kinase anchoring protein 12 beta; A kinase anchoring protein 12 gamma; A-kinase anchor protein 12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; SSeCKS, Gravin, AKAP250
Homo sapiens (human) : AKAP12 (A-kinase anchoring protein 12)  HGNC  Alliance
Mus musculus (house mouse) : Akap12 (A kinase (PRKA) anchor protein (gravin) 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akap12 (A-kinase anchoring protein 12)
Pan paniscus (bonobo/pygmy chimpanzee) : AKAP12 (A-kinase anchoring protein 12)
Canis lupus familiaris (dog) : AKAP12 (A-kinase anchoring protein 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akap12 (A-kinase anchoring protein 12)
Sus scrofa (pig) : AKAP12 (A-kinase anchoring protein 12)
Chlorocebus sabaeus (African green monkey) : AKAP12 (A-kinase anchoring protein 12)
Heterocephalus glaber (naked mole-rat) : Akap12 (A-kinase anchoring protein 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Akap12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 70988
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.