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Gene: Gpnmb (glycoprotein nmb) Rattus norvegicus
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Symbol: Gpnmb
Name: glycoprotein nmb
Description: Predicted to have heparin binding activity; signaling receptor binding activity; and syndecan binding activity. Involved in bone mineralization and osteoblast differentiation. Predicted to localize to the cytoplasmic vesicle and integral component of plasma membrane. Human ortholog(s) of this gene implicated in primary cutaneous amyloidosis. Orthologous to human GPNMB (glycoprotein nmb); INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glycoprotein (transmembrane) nmb; osteoactivin; transmembrane glycoprotein NMB
Orthologs:
Homo sapiens (human) : GPNMB (glycoprotein nmb)  HGNC  Alliance
Mus musculus (house mouse) : Gpnmb (glycoprotein (transmembrane) nmb)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpnmb (glycoprotein nmb)
Pan paniscus (bonobo/pygmy chimpanzee) : GPNMB (glycoprotein nmb)
Canis lupus familiaris (dog) : GPNMB (glycoprotein nmb)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpnmb (glycoprotein nmb)
Sus scrofa (pig) : GPNMB (glycoprotein nmb)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0478,694,447 - 78,715,685 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04143,383,026 - 143,404,104 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4477,161,352 - 77,182,624 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1477,437,481 - 77,458,752 (+)NCBI
Celera472,946,255 - 72,967,354 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gpnmb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 71008
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.