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Gene: Fzd4 (frizzled class receptor 4) Rattus norvegicus
Symbol: Fzd4
Name: frizzled class receptor 4
Description: Exhibits Wnt-protein binding activity and signaling receptor activity. Involved in Wnt signaling pathway and positive regulation of neuron projection arborization. Predicted to localize to several cellular components, including cell surface; dendrite; and glutamatergic synapse. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4); PARTICIPATES IN Wnt signaling pathway; basal cell carcinoma pathway; Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: frizzled family receptor 4; frizzled homolog 4; frizzled homolog 4 (Drosophila); frizzled receptor 4; frizzled receptor 4 (Drosophila); frizzled-4; fz-4; rFz4
Homo sapiens (human) : FZD4 (frizzled class receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Fzd4 (frizzled class receptor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fzd4 (frizzled class receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FZD4 (frizzled class receptor 4)
Canis lupus familiaris (dog) : FZD4 (frizzled class receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fzd4 (frizzled class receptor 4)
Sus scrofa (pig) : FZD4 (frizzled class receptor 4)
Chlorocebus sabaeus (African green monkey) : FZD4 (frizzled class receptor 4)
Heterocephalus glaber (naked mole-rat) : Fzd4 (frizzled class receptor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01153,589,471 - 153,598,376 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,589,471 - 153,598,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01159,893,040 - 159,901,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,953,743 - 145,957,666 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11146,032,165 - 146,036,072 (+)NCBI
Celera1141,540,910 - 141,549,599 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fzd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 71017
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.