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Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
CRRD ID: 71019
Description: Predicted to have ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Involved in regulation of cell population proliferation. Predicted to localize to cytosol and nucleus. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3; SM-20
Homo sapiens (human) : EGLN3 (egl-9 family hypoxia inducible factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Egln3 (egl-9 family hypoxia-inducible factor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln3 (egl-9 family hypoxia inducible factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Canis lupus familiaris (dog) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln3 (egl-9 family hypoxia inducible factor 3)
Sus scrofa (pig) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Chlorocebus sabaeus (African green monkey) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Heterocephalus glaber (naked mole-rat) : Egln3 (egl-9 family hypoxia inducible factor 3)
more info ...
Allele / Splice: Egln3m1Mcwi  
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egln3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 71019
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.