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Gene: Cpb2 (carboxypeptidase B2) Rattus norvegicus
Symbol: Cpb2
Name: carboxypeptidase B2
Description: Exhibits carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Localizes to extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2); PARTICIPATES IN fibrinolysis pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: carboxypeptidase B2 (plasma); carboxypeptidase R; carboxypeptidase U; CPR; CPU; LOC684726; similar to carboxypeptidase B2 (plasma); TAFI; thrombin-activable fibrinolysis inhibitor
Homo sapiens (human) : CPB2 (carboxypeptidase B2)  HGNC  Alliance
Mus musculus (house mouse) : Cpb2 (carboxypeptidase B2 (plasma))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cpb2 (carboxypeptidase B2)
Pan paniscus (bonobo/pygmy chimpanzee) : CPB2 (carboxypeptidase B2)
Canis lupus familiaris (dog) : CPB2 (carboxypeptidase B2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cpb2 (carboxypeptidase B2)
Sus scrofa (pig) : CPB2 (carboxypeptidase B2)
Chlorocebus sabaeus (African green monkey) : CPB2 (carboxypeptidase B2)
Heterocephalus glaber (naked mole-rat) : Cpb2 (carboxypeptidase B2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01557,290,849 - 57,339,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01561,001,889 - 61,050,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41556,104,920 - 56,154,321 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11556,120,686 - 56,170,027 (+)NCBI
Celera1550,189,675 - 50,237,544 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cpb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 71035
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.