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Gene: Epm2a (EPM2A glucan phosphatase, laforin) Rattus norvegicus
Symbol: Epm2a
Name: EPM2A glucan phosphatase, laforin
Description: Predicted to have phosphatase activity; polysaccharide binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including dephosphorylation; regulation of cellular protein localization; and regulation of cellular protein metabolic process. Predicted to colocalize with the polysome. Human ortholog(s) of this gene implicated in Lafora disease and progressive myoclonus epilepsy. Orthologous to human EPM2A (EPM2A glucan phosphatase, laforin); INTERACTS WITH 1,2-dimethylhydrazine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha; epilepsy, progressive myoclonus type 2A; EPM2A, laforin glucan phosphatase; glucan phosphatase; lafora PTPase; laforin; LAFPTPase; LOC684363; similar to Laforin (Lafora PTPase) (LAFPTPase)
Homo sapiens (human) : EPM2A (EPM2A glucan phosphatase, laforin)  HGNC  Alliance
Mus musculus (house mouse) : Epm2a (epilepsy, progressive myoclonic epilepsy, type 2 gene alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epm2a (EPM2A glucan phosphatase, laforin)
Pan paniscus (bonobo/pygmy chimpanzee) : EPM2A (EPM2A glucan phosphatase, laforin)
Canis lupus familiaris (dog) : EPM2A (EPM2A glucan phosphatase, laforin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epm2a (EPM2A glucan phosphatase, laforin)
Sus scrofa (pig) : EPM2A (EPM2A glucan phosphatase, laforin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.015,448,958 - 5,571,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15,448,958 - 5,571,512 (+)Ensembl
Rnor_5.017,100,639 - 7,223,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.116,051,557 - 6,172,313 (+)NCBI
Celera14,243,803 - 4,360,561 (+)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Epm2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 71047
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.