Asic1 (acid sensing ion channel subunit 1) - Chinchilla Research Resource Database
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Gene: Asic1 (acid sensing ion channel subunit 1) Rattus norvegicus
Analyze
Symbol: Asic1
Name: acid sensing ion channel subunit 1
CRRD ID: 71062
Description: Exhibits ion channel activity and monovalent inorganic cation transmembrane transporter activity. Involved in ion transmembrane transport and monovalent inorganic cation transport. Localizes to cell surface and integral component of membrane. Orthologous to human ASIC1 (acid sensing ion channel subunit 1); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Accn2; acid sensing ion channel 1; acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1; amiloride-sensitive cation channel 2, neuronal; BNaC2; brain sodium channel 2; proton gated cation channel ASIC1
Orthologs:
Homo sapiens (human) : ASIC1 (acid sensing ion channel subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Asic1 (acid-sensing (proton-gated) ion channel 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Asic1 (acid sensing ion channel subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ASIC1 (acid sensing ion channel subunit 1)
Canis lupus familiaris (dog) : ASIC1 (acid sensing ion channel subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Asic1 (acid sensing ion channel subunit 1)
Sus scrofa (pig) : ASIC1 (acid sensing ion channel subunit 1)
Chlorocebus sabaeus (African green monkey) : ASIC1 (acid sensing ion channel subunit 1)
Heterocephalus glaber (naked mole-rat) : Asic1 (acid sensing ion channel subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Celera7127,281,326 - 127,309,938 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9062189   PMID:9360943   PMID:10798398   PMID:10829030   PMID:11588175   PMID:11588592   PMID:11842212   PMID:11854527   PMID:11976391   PMID:11988176   PMID:12198124   PMID:12509480  
PMID:12947112   PMID:14960591   PMID:15369669   PMID:15452199   PMID:15470133   PMID:16085050   PMID:16169854   PMID:16505147   PMID:16723538   PMID:16949762   PMID:17204502   PMID:17548344  
PMID:17872465   PMID:17936312   PMID:18094106   PMID:18410516   PMID:18452213   PMID:18534561   PMID:18723775   PMID:19257932   PMID:19376200   PMID:19482897   PMID:19730136   PMID:19812697  
PMID:20019330   PMID:20162006   PMID:20179994   PMID:20185828   PMID:20385551   PMID:20427715   PMID:20442265   PMID:20675379   PMID:20844750   PMID:21346156   PMID:22205392   PMID:22231470  
PMID:22553040   PMID:22760635   PMID:22792205   PMID:22890703   PMID:23994523   PMID:24247984   PMID:24261866   PMID:24573273   PMID:24695733   PMID:24821433   PMID:24939363   PMID:25377529  
PMID:25744567   PMID:25828470   PMID:26174503   PMID:26248594   PMID:26384841   PMID:26562527   PMID:26680001   PMID:26702130   PMID:26715049   PMID:26722526   PMID:26823770   PMID:28321113  
PMID:28825196   PMID:29019932   PMID:29070491   PMID:29086909   PMID:29226878   PMID:29273849   PMID:29739981   PMID:30487596   PMID:30720055   PMID:30938088   PMID:31675256   PMID:32502377  
PMID:32702049  


Genomics

Comparative Map Data
Asic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07141,324,714 - 141,354,937 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,414,656 - 138,443,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,491,092 - 138,517,829 (+)NCBI
Celera7127,281,326 - 127,309,938 (+)NCBICelera
Cytogenetic Map7q36NCBI
ASIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1250,057,548 - 50,083,611 (+)EnsemblGRCh38hg38GRCh38
GRCh381250,057,596 - 50,083,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371250,451,420 - 50,477,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,737,754 - 48,763,661 (+)NCBINCBI36hg18NCBI36
Build 341248,737,753 - 48,763,660NCBI
Celera1249,246,955 - 49,272,856 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1247,485,455 - 47,510,311 (+)NCBIHuRef
CHM1_11250,417,567 - 50,443,552 (+)NCBICHM1_1
Asic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,568,090 - 99,599,011 (+)NCBI
GRCm381599,670,197 - 99,701,130 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,670,368 - 99,701,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,501,149 - 99,531,559 (+)NCBIGRCm37mm9NCBIm37
MGSCv361599,498,752 - 99,529,162 (+)NCBImm8
Celera15101,826,413 - 101,856,974 (+)NCBICelera
Cytogenetic Map15F1NCBI
Asic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547635,638 - 658,541 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547635,714 - 658,541 (+)NCBIChiLan1.0ChiLan1.0
ASIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11239,569,149 - 39,593,822 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01238,672,253 - 38,698,247 (-)NCBIMhudiblu_PPA_v0panPan3
ASIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl274,638,812 - 4,648,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1274,638,826 - 4,663,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Asic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365127,720,591 - 7,746,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,947,382 - 15,991,877 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,965,082 - 15,991,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,354,884 - 16,365,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASIC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1146,287,787 - 46,314,177 (+)Ensembl
ChlSab1.11146,286,665 - 46,313,016 (+)NCBI
Asic1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248162,228,440 - 2,253,798 (-)NCBI

Position Markers
AU047966  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07141,326,181 - 141,326,422NCBIRnor6.0
Rnor_5.0X115,830,829 - 115,831,070UniSTSRnor5.0
RGSC_v3.47138,414,516 - 138,414,757UniSTSRGSC3.4
Celera7127,281,186 - 127,281,427UniSTS
Cytogenetic Map7q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7120746024145692398Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7121654760145729302Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7121986439143965591Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7122421276143965415Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7129412003145729302Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1076
Count of miRNA genes:258
Interacting mature miRNAs:332
Transcripts:ENSRNOT00000025476, ENSRNOT00000047887
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 68 5
Low 3 43 22 6 19 6 6 35 35 6
Below cutoff 27 27 27 8 10 6 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01052645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB049451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ309926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO398759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV721841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000077175   ⟹   ENSRNOP00000072206
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7141,346,398 - 141,352,884 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084075   ⟹   ENSRNOP00000070082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7141,326,950 - 141,352,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088191   ⟹   ENSRNOP00000068902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7141,326,321 - 141,354,937 (+)Ensembl
RefSeq Acc Id: NM_024154   ⟹   NP_077068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,326,321 - 141,354,937 (+)NCBI
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBI
RGSC_v3.47138,414,656 - 138,443,272 (+)RGD
Celera7127,281,326 - 127,309,938 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257378   ⟹   XP_006257440
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,346,089 - 141,354,937 (+)NCBI
Rnor_5.0X115,830,166 - 115,859,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595124   ⟹   XP_017450613
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,346,072 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595125   ⟹   XP_017450614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,326,319 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595126   ⟹   XP_017450615
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,324,714 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595127   ⟹   XP_017450616
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,326,527 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595128   ⟹   XP_017450617
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,346,120 - 141,354,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595129   ⟹   XP_017450618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,346,143 - 141,354,937 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077068   ⟸   NM_024154
- UniProtKB: P55926 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257440   ⟸   XM_006257378
- Peptide Label: isoform X2
- UniProtKB: P55926 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450615   ⟸   XM_017595126
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450614   ⟸   XM_017595125
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450616   ⟸   XM_017595127
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450613   ⟸   XM_017595124
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450617   ⟸   XM_017595128
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017450618   ⟸   XM_017595129
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000072206   ⟸   ENSRNOT00000077175
RefSeq Acc Id: ENSRNOP00000070082   ⟸   ENSRNOT00000084075
RefSeq Acc Id: ENSRNOP00000068902   ⟸   ENSRNOT00000088191

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71062 AgrOrtholog
Ensembl Genes ENSRNOG00000059765 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068902 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070082 UniProtKB/TrEMBL
  ENSRNOP00000072206 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000084075 UniProtKB/TrEMBL
  ENSRNOT00000088191 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ENaC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENaC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79123 UniProtKB/Swiss-Prot
NCBI Gene 79123 ENTREZGENE
PANTHER PTHR11690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asic1 PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ENaC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.37385 ENTREZGENE
UniProt A0A0G2JX02_RAT UniProtKB/TrEMBL
  ASIC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88762 UniProtKB/Swiss-Prot
  Q91YB8 UniProtKB/Swiss-Prot
  Q99NA1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Asic1  acid sensing ion channel subunit 1  Asic1  acid sensing ion channel 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Asic1  acid sensing ion channel 1  Asic1  acid-sensing (proton-gated) ion channel 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Asic1  acid-sensing (proton-gated) ion channel 1  Accn2  amiloride-sensitive cation channel 2, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Accn2  amiloride-sensitive cation channel 2, neuronal      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression splice variant ASIC-beta is expressed specifically in a subset of sensory neurons  
gene_process its heterologous expression induces an amiloride-sensitive cation (Na(+) > Ca(2+) > K(+)) channel which is transiently activated by rapid extracellular acidification 724707