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Gene: Cyp11b3 (cytochrome P450, family 11, subfamily b, polypeptide 3) Rattus norvegicus
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Symbol: Cyp11b3
Name: cytochrome P450, family 11, subfamily b, polypeptide 3
Description: Exhibits corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in adrenal gland development; response to peptide hormone; and steroid metabolic process. Predicted to localize to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); dilated cardiomyopathy 1H; hypertension (multiple); and primary hyperaldosteronism. Orthologous to human CYP11B2 (cytochrome P450 family 11 subfamily B member 2); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CYPXIB3; cytochrome P450, subfamily 11B, polypeptide 3
Orthologs:
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07116,155,928 - 116,161,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,059,008 - 116,064,497 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,013,335 - 113,018,824 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17113,047,564 - 113,053,054 (-)NCBI
Celera7103,180,975 - 103,186,464 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp11b3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 727886
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.