Gene: Gjb2 (gap junction protein, beta 2) Rattus norvegicus
Symbol: Gjb2
Name: gap junction protein, beta 2
Description: Exhibits gap junction channel activity; involved in several processes, including aging, animal organ development, and cellular response to hormone stimulus; localizes to several cellular components, including the astrocyte projection, cell body, and cytoplasm; used to study hepatocellular carcinoma and lung adenocarcinoma; biomarker of autoimmune thyroiditis, extrahepatic cholestasis, ischemia, sensorineural hearing loss, and urethral obstruction; orthologous to human GJB2 (gap junction protein beta 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: connexin 26; connexin-26; Cx26; CXN-26; gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; MGC93804
Homo sapiens (human) : GJB2 (gap junction protein beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Gjb2 (gap junction protein, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gjb2 (gap junction protein beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GJB2 (gap junction protein beta 2)
Canis lupus familiaris (dog) : GJB2 (gap junction protein beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gjb2 (gap junction protein beta 2)
Sus scrofa (pig) : GJB2 (gap junction protein beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01537,377,313 - 37,394,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01541,224,497 - 41,236,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,153,526 - 36,159,490 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11536,169,226 - 36,175,190 (-)NCBI
Celera1530,972,813 - 30,978,777 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gjb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 728891
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.