Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ABCB1 (ATP binding cassette subfamily B member 1) Homo sapiens
Analyze
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Description: Exhibits several functions, including ATP binding activity; ATPase-coupled intramembrane lipid transporter activity; and transmembrane transporter activity. Involved in several processes, including G2/M transition of mitotic cell cycle; lipid translocation; and regulation of anion transport. Localizes to the apical plasma membrane and cell surface. Implicated in several diseases, including Behcet's disease; allergic rhinitis; carcinoma (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Biomarker of asthma; familial temporal lobe epilepsy 3; nephroblastoma; ovarian cancer; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; ATP-dependent translocase ABCB1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; PGY1; phospholipid transporter ABCB1
Orthologs:
Mus musculus (house mouse) : Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abcb1a (ATP binding cassette subfamily B member 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcb1 (ATP binding cassette subfamily B member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB1 (ATP binding cassette subfamily B member 1)
Canis lupus familiaris (dog) : ABCB1 (ATP binding cassette subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb1 (ATP binding cassette subfamily B member 1)
Sus scrofa (pig) : ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)
Chlorocebus sabaeus (African green monkey) : ABCB1 (ATP binding cassette subfamily B member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl787,503,017 - 87,713,323 (-)Ensembl
GRCh38 Ensembl787,503,633 - 87,713,323 (-)Ensembl
GRCh38787,503,017 - 87,713,323 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37787,133,179 - 87,342,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,970,884 - 87,180,500 (-)NCBINCBI36hg18NCBI36
Build 34786,777,598 - 86,987,215NCBI
Celera781,837,832 - 82,047,176 (-)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,744,182 - 81,952,578 (-)NCBIHuRef
CHM1_1787,063,281 - 87,272,756 (-)NCBICHM1_1
CRA_TCAGchr7v2786,464,691 - 86,673,953 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated