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Gene: GAD1 (glutamate decarboxylase 1) Homo sapiens
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Symbol: GAD1
Name: glutamate decarboxylase 1
Description: Exhibits glutamate decarboxylase activity. Predicted to be involved in glutamate decarboxylation to succinate; neurotransmitter secretion; and protein-pyridoxal-5-phosphate linkage. Predicted to localize to clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane and plasma membrane. Implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 67 kDa glutamic acid decarboxylase; CPSQ1; FLJ45882; GAD; GAD-67; GAD67; glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 67 kDa isoform; SCP
Orthologs:
Mus musculus (house mouse) : Gad1 (glutamate decarboxylase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gad1 (glutamate decarboxylase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gad1 (glutamate decarboxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GAD1 (glutamate decarboxylase 1)
Canis lupus familiaris (dog) : GAD1 (glutamate decarboxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gad1 (glutamate decarboxylase 1)
Sus scrofa (pig) : GAD1 (glutamate decarboxylase 1)
Chlorocebus sabaeus (African green monkey) : GAD1 (glutamate decarboxylase 1)
Heterocephalus glaber (naked mole-rat) : Gad1 (glutamate decarboxylase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2170,813,213 - 170,861,151 (+)EnsemblGRCh38hg38GRCh38
GRCh382170,813,210 - 170,861,151 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372171,673,200 - 171,717,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362171,381,446 - 171,425,907 (+)NCBINCBI36hg18NCBI36
Build 342171,498,706 - 171,524,775NCBI
Celera2165,289,914 - 165,334,327 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2163,562,349 - 163,606,375 (+)NCBIHuRef
CHM1_12171,679,435 - 171,723,884 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GAD1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730853
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.