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Gene: ANXA1 (annexin A1) Homo sapiens
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Symbol: ANXA1
Name: annexin A1
Description: Exhibits calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and phospholipase A2 inhibitor activity. Involved in several processes, including leukocyte chemotaxis; regulation of T cell activation; and regulation of vesicle-mediated transport. Localizes to several cellular components, including cornified envelope; extracellular exosome; and extrinsic component of external side of plasma membrane. Colocalizes with actin filament. Implicated in brain ischemia and pancreatic cancer. Biomarker of several diseases, including astrocytoma; dry eye syndrome; ductal carcinoma in situ; invasive ductal carcinoma; and keratosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: annexin I (lipocortin I); annexin-1; ANX1; calpactin II; calpactin-2; chromobindin-9; lipocortin I; LPC1; p35; phospholipase A2 inhibitory protein
Orthologs:
Mus musculus (house mouse) : Anxa1 (annexin A1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Anxa1 (annexin A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Anxa1 (annexin A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ANXA1 (annexin A1)
Canis lupus familiaris (dog) : ANXA1 (annexin A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Anxa1 (annexin A1)
Sus scrofa (pig) : ANXA1 (annexin A1)
Chlorocebus sabaeus (African green monkey) : ANXA1 (annexin A1)
Heterocephalus glaber (naked mole-rat) : Anxa1 (annexin A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37975,766,721 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBI
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,496 - 75,932,176 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ANXA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730873
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.