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Gene: NPPA (natriuretic peptide A) Homo sapiens
Symbol: NPPA
Name: natriuretic peptide A
Description: Exhibits hormone receptor binding activity; neuropeptide hormone activity; and neuropeptide receptor binding activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of heart contraction; and regulation of ion transmembrane transport. Localizes to the protein-containing complex. Implicated in coronary artery disease; familial atrial fibrillation; myocardial infarction; peritonitis; and renal hypertension. Biomarker of several diseases, including chronic kidney disease; diabetic retinopathy; heart disease (multiple); obesity; and renal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ANF; ANP; ATFB6; atrial natriuretic factor; atriopeptin; ATRST2; cardiodilatin; cardiodilatin-related peptide; cardionatrin; CDD; CDD-ANF; CDP; natriuretic peptide precursor A; natriuretic peptide precursor A variant 1; natriuretic peptides A; PND; prepronatriodilatin
Mus musculus (house mouse) : Nppa (natriuretic peptide type A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nppa (natriuretic peptide A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppa (natriuretic peptide A)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPA (natriuretic peptide A)
Canis lupus familiaris (dog) : NPPA (natriuretic peptide A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppa (natriuretic peptide A)
Sus scrofa (pig) : NPPA (natriuretic peptide A)
Chlorocebus sabaeus (green monkey) : NPPA (natriuretic peptide A)
Heterocephalus glaber (naked mole-rat) : Nppa (natriuretic peptide A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,845,709 - 11,848,345 (-)Ensembl
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBINCBI36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NPPA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730878
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.