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Gene: HRAS (HRas proto-oncogene, GTPase) Homo sapiens
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Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Description: Exhibits GTPase activity; protein C-terminus binding activity; and purine ribonucleoside binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of GTPase activity; and regulation of protein localization to membrane. Localizes to several cellular components, including the Golgi apparatus; glutamatergic synapse; and nucleoplasm. Implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Biomarker of Alzheimer's disease; endometrial carcinoma; glioblastoma multiforme; liver disease (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-BAS/HAS; C-H-RAS; C-HA-RAS1; c-has/bas p21 protein; c-K-ras; c-Ki-ras; c-ras-Ki-2 activated oncogene; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; GTPase KRas; H-Ras-1; H-RASIDX; ha-Ras; Ha-Ras1 proto-oncoprotein; HAMSV; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; HRAS1; K-RAS; K-Ras 2; Ki-Ras; KRAS; KRAS2; N-RAS; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; RASH1; RASK2; transformation gene: oncogene HAMSV; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Hras (Harvey rat sarcoma virus oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hras (HRas proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hras (HRas proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : HRAS (HRas proto-oncogene, GTPase)
Canis lupus familiaris (dog) : HRAS (HRas proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hras (HRas proto-oncogene, GTPase)
Sus scrofa (pig) : HRAS (HRas proto-oncogene, GTPase)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(CAG-HRAS*G12V)250Htsu  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811532,242 - 535,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711532,242 - 535,561 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611522,242 - 525,550 (-)NCBINCBI36hg18NCBI36
Build 3411522,242 - 525,550NCBI
Celera11594,708 - 598,010 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11346,981 - 349,115 (-)NCBIHuRef
CHM1_111529,852 - 534,482 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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