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Gene: NFKB1 (nuclear factor kappa B subunit 1) Homo sapiens
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Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription coactivator binding activity; and actinin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to mechanical stimulus; and regulation of cellular biosynthetic process. Localizes to cytosol; mitochondrion; and nucleoplasm. Implicated in breast cancer; common variable immunodeficiency; lung non-small cell carcinoma; melanoma; and prostate cancer. Biomarker of lung non-small cell carcinoma and pancreatic adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CVID12; DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappa-B1; NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; nuclear factor kappa-B DNA binding subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
Orthologs:
Mus musculus (house mouse) : Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfkb1 (nuclear factor kappa B subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfkb1 (nuclear factor kappa B subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NFKB1 (nuclear factor kappa B subunit 1)
Canis lupus familiaris (dog) : NFKB1 (nuclear factor kappa B subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfkb1 (nuclear factor kappa B subunit 1)
Sus scrofa (pig) : NFKB1 (nuclear factor kappa B subunit 1)
Chlorocebus sabaeus (African green monkey) : NFKB1 (nuclear factor kappa B subunit 1)
Heterocephalus glaber (naked mole-rat) : Nfkb1 (nuclear factor kappa B subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4102,501,331 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh384102,501,266 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374103,422,486 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBI
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated