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Gene: IL18 (interleukin 18) Homo sapiens
Symbol: IL18
Name: interleukin 18
Description: Exhibits cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Localizes to extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; biliary atresia; hepatitis B; and vasculitis (multiple). Biomarker of several diseases, including autoimmune hypersensitivity disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: iboctadekin; IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL1F4; interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; interleukin-18; MGC12320
Mus musculus (house mouse) : Il18 (interleukin 18)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il18 (interleukin 18)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il18 (interleukin 18)
Pan paniscus (bonobo/pygmy chimpanzee) : IL18 (interleukin 18)
Canis lupus familiaris (dog) : IL18 (interleukin 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il18 (interleukin 18)
Sus scrofa (pig) : IL18 (interleukin 18)
Chlorocebus sabaeus (African green monkey) : IL18 (interleukin 18)
Heterocephalus glaber (naked mole-rat) : Il18 (interleukin 18)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3811112,143,251 - 112,164,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711112,013,974 - 112,034,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL18
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730894
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.