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Gene: Il18 (interleukin 18) Mus musculus
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Symbol: Il18
Name: interleukin 18
Description: Exhibits cytokine activity. Involved in several processes, including T-helper 1 cell cytokine production; lipid homeostasis; and positive regulation of cell differentiation. Localizes to the extracellular space. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; biliary atresia; hepatitis B; and vasculitis (multiple). Is expressed in several structures, including back skin; colon; dorsal aorta; lymphatic system; and reproductive system. Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1,2-dichloroethane; 1-chloro-2,4,6-trinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IFN-gamma-inducing factor; Igif; IL-1 gamma; Il-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
Orthologs:
Homo sapiens (human) : IL18 (interleukin 18)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il18 (interleukin 18)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il18 (interleukin 18)
Pan paniscus (bonobo/pygmy chimpanzee) : IL18 (interleukin 18)
Canis lupus familiaris (dog) : IL18 (interleukin 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il18 (interleukin 18)
Sus scrofa (pig) : IL18 (interleukin 18)
Chlorocebus sabaeus (African green monkey) : IL18 (interleukin 18)
Heterocephalus glaber (naked mole-rat) : Il18 (interleukin 18)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl950,554,827 - 50,581,840 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9 A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Il18
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730895
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.