NGFR (nerve growth factor receptor) - Chinchilla Research Resource Database
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Gene: NGFR (nerve growth factor receptor) Homo sapiens
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Symbol: NGFR
Name: nerve growth factor receptor
CRRD ID: 730911
Description: Exhibits several functions, including calmodulin binding activity; death receptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of nitrogen compound metabolic process. Localizes to plasma membrane. Implicated in Alzheimer's disease and mental depression. Biomarker of several diseases, including Hirschsprung's disease; Lewy body dementia; artery disease (multiple); neurodegenerative disease (multiple); and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; p75(NTR); p75NTR; TNFR superfamily, member 16; TNFRSF16; tumor necrosis factor receptor superfamily member 16
Orthologs:
Mus musculus (house mouse) : Ngfr (nerve growth factor receptor (TNFR superfamily, member 16))  MGI  Alliance
Rattus norvegicus (Norway rat) : Ngfr (nerve growth factor receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngfr (nerve growth factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGFR (nerve growth factor receptor)
Canis lupus familiaris (dog) : NGFR (nerve growth factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngfr (nerve growth factor receptor)
Sus scrofa (pig) : NGFR (nerve growth factor receptor)
Chlorocebus sabaeus (African green monkey) : NGFR (nerve growth factor receptor)
Heterocephalus glaber (naked mole-rat) : Ngfr (nerve growth factor receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1749,495,293 - 49,515,008 (+)EnsemblGRCh38hg38GRCh38
GRCh381749,495,293 - 49,515,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,572,655 - 47,592,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,927,666 - 44,947,360 (+)NCBINCBI36hg18NCBI36
Build 341744,927,665 - 44,947,360NCBI
Celera1744,027,660 - 44,047,391 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,937,638 - 42,957,366 (+)NCBIHuRef
CHM1_11747,637,800 - 47,657,550 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (ISO)
celecoxib  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
clothianidin  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (EXP,ISO)
fenarimol  (ISO)
fenoprofen  (EXP)
fenvalerate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fonofos  (EXP)
fructose  (ISO)
Fusarenone X  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (EXP,ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
glyceollin  (EXP)
haloperidol  (ISO)
ibuprofen  (EXP)
indometacin  (EXP)
ketoconazole  (ISO)
ketoprofen  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (EXP)
naproxen  (EXP,ISO)
nicotine  (EXP)
O-methyleugenol  (EXP)
oxaprozin  (EXP)
p-menthan-3-ol  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
pentanal  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (EXP)
propiconazole  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quetiapine fumarate  (ISO)
resveratrol  (EXP,ISO)
risperidone  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (EXP)
sulindac sulfone  (EXP)
sumatriptan  (ISO)
tebuconazole  (ISO)
terbufos  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP,TAS)
axon guidance  (ISO)
cellular glucose homeostasis  (ISS)
cellular response to amyloid-beta  (IDA)
cellular response to oxidative stress  (ISO)
central nervous system development  (ISO)
circadian regulation of gene expression  (ISS)
circadian rhythm  (ISO)
detection of temperature stimulus  (ISO)
dorsal aorta development  (ISO)
glucose homeostasis  (ISS)
hair follicle morphogenesis  (ISO)
intracellular protein transport  (ISS)
membrane protein intracellular domain proteolysis  (TAS)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (TAS)
negative regulation of axonogenesis  (TAS)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IGI)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (TAS)
negative regulation of dendritic spine development  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of hair follicle development  (ISO)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (ISO)
nerve development  (ISO)
neuron apoptotic process  (IGI)
neurotrophin TRK receptor signaling pathway  (TAS)
positive regulation of apoptotic process  (TAS)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of axonogenesis  (TAS)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of odontogenesis of dentin-containing tooth  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to nucleus  (IDA)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
regulation of cell death  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (TAS)
regulation of gene expression  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
response to lipopolysaccharide  (ISO)
response to wounding  (ISO)
Rho protein signal transduction  (IBA,IDA)
sensory perception of pain  (ISO)
signal transduction  (ISO)
skeletal muscle cell differentiation  (ISO)
skin development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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40. Perry EK, etal., Alzheimer Dis Assoc Disord. 1993 Summer;7(2):69-79.
41. Pipeline to import KEGG annotations from KEGG into RGD
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43. RGD automated import pipeline for gene-chemical interactions
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45. Salehi A, etal., Exp Neurol. 2000 Jan;161(1):245-58.
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Additional References at PubMed
PMID:1281863   PMID:1316918   PMID:1324502   PMID:1846035   PMID:2850481   PMID:2989274   PMID:3006050   PMID:3008331   PMID:3020711   PMID:3022937   PMID:7541035   PMID:7541633  
PMID:7903404   PMID:8407983   PMID:8614797   PMID:8627329   PMID:8889548   PMID:9252186   PMID:9368064   PMID:9575168   PMID:9626059   PMID:9665396   PMID:9867838   PMID:9915784  
PMID:9927421   PMID:10022904   PMID:10485890   PMID:10514511   PMID:10544233   PMID:10545116   PMID:10595511   PMID:10764727   PMID:10985348   PMID:11150334   PMID:11201742   PMID:11244088  
PMID:11278287   PMID:11279055   PMID:11487608   PMID:11729324   PMID:11756426   PMID:11756498   PMID:11818506   PMID:11830582   PMID:11927634   PMID:12011108   PMID:12034707   PMID:12107411  
PMID:12163480   PMID:12371150   PMID:12376548   PMID:12414813   PMID:12422217   PMID:12426574   PMID:12460612   PMID:12477932   PMID:12604596   PMID:12672029   PMID:12676795   PMID:12682012  
PMID:12692556   PMID:12716928   PMID:12768436   PMID:12787561   PMID:12789270   PMID:12821676   PMID:12821936   PMID:12843241   PMID:12913006   PMID:12951563   PMID:12963025   PMID:14593116  
PMID:14689592   PMID:14960584   PMID:14966521   PMID:14985763   PMID:15015775   PMID:15128850   PMID:15131306   PMID:15165637   PMID:15258592   PMID:15310753   PMID:15337528   PMID:15378608  
PMID:15489334   PMID:15523689   PMID:15681836   PMID:15694321   PMID:15701642   PMID:15721744   PMID:15784962   PMID:15953414   PMID:16099913   PMID:16215275   PMID:16215672   PMID:16344560  
PMID:16460673   PMID:16498402   PMID:16555252   PMID:16630834   PMID:16712417   PMID:16826429   PMID:16893414   PMID:16951226   PMID:16997282   PMID:17110619   PMID:17196528   PMID:17287525  
PMID:17335080   PMID:17349981   PMID:17355907   PMID:17357149   PMID:17492429   PMID:17510309   PMID:17531524   PMID:17582777   PMID:17603629   PMID:17619016   PMID:17696644   PMID:17703412  
PMID:17850422   PMID:17947706   PMID:17971243   PMID:17986144   PMID:18029348   PMID:18036543   PMID:18081157   PMID:18196575   PMID:18203754   PMID:18221326   PMID:18305571   PMID:18319596  
PMID:18394312   PMID:18428117   PMID:18462868   PMID:18470533   PMID:18477014   PMID:18540978   PMID:18566344   PMID:19041213   PMID:19066726   PMID:19072833   PMID:19086053   PMID:19131967  
PMID:19169037   PMID:19177265   PMID:19225519   PMID:19240061   PMID:19258923   PMID:19301169   PMID:19386345   PMID:19490633   PMID:19598235   PMID:19615036   PMID:19758188   PMID:19918800  
PMID:19945432   PMID:20022966   PMID:20159974   PMID:20219210   PMID:20237496   PMID:20351714   PMID:20503287   PMID:20530577   PMID:20549701   PMID:20596026   PMID:20659559   PMID:20680101  
PMID:20854189   PMID:21097678   PMID:21123453   PMID:21142793   PMID:21151024   PMID:21178583   PMID:21307265   PMID:21343882   PMID:21393506   PMID:21397006   PMID:21418516   PMID:21503896  
PMID:21807134   PMID:21814043   PMID:21851375   PMID:21873635   PMID:21900206   PMID:21938001   PMID:21982860   PMID:22040987   PMID:22068036   PMID:22138126   PMID:22161836   PMID:22170235  
PMID:22207443   PMID:22343487   PMID:22419851   PMID:22454143   PMID:22558167   PMID:22566094   PMID:22610502   PMID:22635104   PMID:22706116   PMID:22710983   PMID:22932111   PMID:22954667  
PMID:23017601   PMID:23065828   PMID:23105112   PMID:23105113   PMID:23260665   PMID:23268325   PMID:23300742   PMID:23371454   PMID:23471969   PMID:23489213   PMID:23535732   PMID:23559013  
PMID:23576602   PMID:23598407   PMID:23598854   PMID:23600400   PMID:23616554   PMID:23626764   PMID:23642664   PMID:23820422   PMID:23831066   PMID:23975178   PMID:24026251   PMID:24047966  
PMID:24226422   PMID:24333329   PMID:24413464   PMID:24481864   PMID:24519935   PMID:24582280   PMID:24590808   PMID:24604282   PMID:24799129   PMID:24825909   PMID:24831840   PMID:24905361  
PMID:24914971   PMID:24976126   PMID:25093680   PMID:25149537   PMID:25180603   PMID:25200140   PMID:25227100   PMID:25244921   PMID:25321086   PMID:25329094   PMID:25330297   PMID:25351876  
PMID:25491371   PMID:25509351   PMID:25613138   PMID:25666623   PMID:25708205   PMID:25739328   PMID:25748048   PMID:25816145   PMID:26093937   PMID:26119933   PMID:26122862   PMID:26268439  
PMID:26278479   PMID:26311773   PMID:26408608   PMID:26462037   PMID:26646181   PMID:26700963   PMID:26843908   PMID:26871627   PMID:26897248   PMID:26984177   PMID:26984409   PMID:27056327  
PMID:27084575   PMID:27120782   PMID:27178356   PMID:27251195   PMID:27264679   PMID:27282385   PMID:27328305   PMID:27469433   PMID:27469492   PMID:27519317   PMID:27577679   PMID:27726026  
PMID:27788242   PMID:27802234   PMID:27804051   PMID:27808583   PMID:27863492   PMID:28127619   PMID:28215302   PMID:28229962   PMID:28253191   PMID:28426529   PMID:28447720   PMID:28534989  
PMID:28537420   PMID:28560678   PMID:28698670   PMID:28821608   PMID:29037860   PMID:29125884   PMID:29208672   PMID:29215016   PMID:29255171   PMID:29478902   PMID:29499660   PMID:29584618  
PMID:29678478   PMID:29867188   PMID:29930101   PMID:30081046   PMID:30194166   PMID:30428894   PMID:30859186   PMID:30941646   PMID:30977102   PMID:31019292   PMID:31060779   PMID:31118427  
PMID:31296846   PMID:31299366   PMID:31331058   PMID:31353867   PMID:31362891   PMID:31569361   PMID:31742606   PMID:32770055   PMID:32814053  


Genomics

Comparative Map Data
NGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1749,495,293 - 49,515,008 (+)EnsemblGRCh38hg38GRCh38
GRCh381749,495,293 - 49,515,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,572,655 - 47,592,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,927,666 - 44,947,360 (+)NCBINCBI36hg18NCBI36
Build 341744,927,665 - 44,947,360NCBI
Celera1744,027,660 - 44,047,391 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,937,638 - 42,957,366 (+)NCBIHuRef
CHM1_11747,637,800 - 47,657,550 (+)NCBICHM1_1
Ngfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,459,644 - 95,478,524 (-)NCBI
GRCm381195,568,818 - 95,587,698 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,568,818 - 95,587,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,430,132 - 95,449,012 (-)NCBIGRCm37mm9NCBIm37
MGSCv361195,384,908 - 95,403,788 (-)NCBImm8
Celera11105,207,524 - 105,226,387 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Ngfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01083,389,828 - 83,408,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,389,847 - 83,408,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,198,396 - 83,216,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,262,804 - 84,281,006 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11084,277,173 - 84,295,376 (-)NCBI
Celera1079,287,338 - 79,305,497 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ngfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,030,252 - 12,047,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,030,303 - 12,047,305 (-)NCBIChiLan1.0ChiLan1.0
NGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1178,075,301 - 8,094,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,075,316 - 8,094,966 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0178,089,600 - 8,109,361 (-)NCBIMhudiblu_PPA_v0panPan3
NGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl925,601,074 - 25,623,274 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1925,598,468 - 25,621,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ngfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649012,038,500 - 12,057,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,699,427 - 25,720,357 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,699,410 - 25,720,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,702,140 - 25,722,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGFR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1669,894,139 - 69,912,189 (+)Ensembl
ChlSab1.11669,894,000 - 69,914,209 (+)NCBI
Ngfr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247955,623,686 - 5,639,545 (+)NCBI

Position Markers
RH78089  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,592,157 - 47,592,283UniSTSGRCh37
Build 361744,947,156 - 44,947,282RGDNCBI36
Celera1744,047,166 - 44,047,292RGD
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q21-q22UniSTS
HuRef1742,957,141 - 42,957,267UniSTS
GeneMap99-GB4 RH Map17340.35UniSTS
D17S733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,580,128 - 47,580,320UniSTSGRCh37
Build 361744,935,127 - 44,935,319RGDNCBI36
Celera1744,035,133 - 44,035,321RGD
Cytogenetic Map17q21-q22UniSTS
HuRef1742,945,111 - 42,945,307UniSTS
RH76193  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,590,397 - 47,590,598UniSTSGRCh37
Build 361744,945,396 - 44,945,597RGDNCBI36
Celera1744,045,406 - 44,045,607RGD
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q21-q22UniSTS
HuRef1742,955,381 - 42,955,582UniSTS
D17S1169  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,582,070 - 47,582,177UniSTSGRCh37
Build 361744,937,069 - 44,937,176RGDNCBI36
Celera1744,037,071 - 44,037,187RGD
Cytogenetic Map17q21-q22UniSTS
HuRef1742,947,057 - 42,947,163UniSTS
GDB:180972  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,591,982 - 47,592,330UniSTSGRCh37
Build 361744,946,981 - 44,947,329RGDNCBI36
Celera1744,046,991 - 44,047,339RGD
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q21-q22UniSTS
HuRef1742,956,966 - 42,957,314UniSTS
SHGC-108018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,587,040 - 47,587,350UniSTSGRCh37
Build 361744,942,039 - 44,942,349RGDNCBI36
Celera1744,042,050 - 44,042,360RGD
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q21-q22UniSTS
HuRef1742,952,026 - 42,952,336UniSTS
TNG Radiation Hybrid Map1722534.0UniSTS
NGFR  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,592,029 - 47,592,207UniSTSGRCh37
Build 361744,947,028 - 44,947,206RGDNCBI36
Celera1744,047,038 - 44,047,216RGD
HuRef1742,957,013 - 42,957,191UniSTS
WI-18509  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,592,238 - 47,592,337UniSTSGRCh37
Build 361744,947,237 - 44,947,336RGDNCBI36
Celera1744,047,247 - 44,047,346RGD
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q21-q22UniSTS
HuRef1742,957,222 - 42,957,321UniSTS
GeneMap99-GB4 RH Map17341.93UniSTS
Whitehead-RH Map17388.1UniSTS
NCBI RH Map17638.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2596
Count of miRNA genes:840
Interacting mature miRNAs:1013
Transcripts:ENST00000172229, ENST00000504201, ENST00000509200
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 18 11 11
Medium 1682 1784 1410 419 363 264 3179 1133 1497 149 924 806 161 1108 1915 1
Low 643 806 278 182 738 175 1064 965 1897 236 456 690 12 1 96 781 1 1
Below cutoff 67 389 30 21 727 24 93 92 315 31 70 82 1 81 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000172229   ⟹   ENSP00000172229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,495,293 - 49,515,008 (+)Ensembl
RefSeq Acc Id: ENST00000504201   ⟹   ENSP00000421731
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,497,391 - 49,513,372 (+)Ensembl
RefSeq Acc Id: ENST00000509200   ⟹   ENSP00000421514
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,496,624 - 49,506,385 (+)Ensembl
RefSeq Acc Id: NM_002507   ⟹   NP_002498
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,495,293 - 49,515,008 (+)NCBI
GRCh371747,572,655 - 47,592,382 (+)ENTREZGENE
Build 361744,927,666 - 44,947,360 (+)NCBI Archive
HuRef1742,937,638 - 42,957,366 (+)ENTREZGENE
CHM1_11747,637,800 - 47,657,550 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002498   ⟸   NM_002507
- Peptide Label: precursor
- UniProtKB: P08138 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000421731   ⟸   ENST00000504201
RefSeq Acc Id: ENSP00000421514   ⟸   ENST00000509200
RefSeq Acc Id: ENSP00000172229   ⟸   ENST00000172229
Protein Domains
Death

Promoters
RGD ID:6794373
Promoter ID:HG_KWN:26534
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid,   NB4
Transcripts:NM_002507
Position:
Human AssemblyChrPosition (strand)Source
Build 361744,927,449 - 44,927,949 (+)MPROMDB
RGD ID:6811275
Promoter ID:HG_ACW:35173
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour
Transcripts:NGFR.BAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361744,928,686 - 44,929,186 (+)MPROMDB
RGD ID:7235587
Promoter ID:EPDNEW_H23539
Type:initiation region
Name:NGFR_1
Description:nerve growth factor receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,495,293 - 49,495,353EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48520885-49511208)x1 copy number loss See cases [RCV000053431] Chr17:48520885..49511208 [GRCh38]
Chr17:46598247..47588570 [GRCh37]
Chr17:43953246..44943569 [NCBI36]
Chr17:17q21.32-21.33
pathogenic
GRCh38/hg38 17q21.32-22(chr17:49137864-52147810)x1 copy number loss See cases [RCV000053432] Chr17:49137864..52147810 [GRCh38]
Chr17:47215226..50225170 [GRCh37]
Chr17:44570225..47580169 [NCBI36]
Chr17:17q21.32-22
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q21.33(chr17:49361155-50269440)x1 copy number loss See cases [RCV000139901] Chr17:49361155..50269440 [GRCh38]
Chr17:47438517..48346801 [GRCh37]
Chr17:44793516..45701800 [NCBI36]
Chr17:17q21.33
pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48450628-49552921)x3 copy number gain See cases [RCV000143451] Chr17:48450628..49552921 [GRCh38]
Chr17:46527990..47630283 [GRCh37]
Chr17:43882989..44985282 [NCBI36]
Chr17:17q21.32-21.33
uncertain significance
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1 copy number loss not provided [RCV000513510] Chr17:46481089..51396368 [GRCh37]
Chr17:17q21.32-22
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_002507.4(NGFR):c.318G>A (p.Val106=) single nucleotide variant not provided [RCV000923250] Chr17:49506408 [GRCh38]
Chr17:47583770 [GRCh37]
Chr17:17q21.33
likely benign
NM_002507.4(NGFR):c.1185C>T (p.Ser395=) single nucleotide variant not provided [RCV000973217] Chr17:49512910 [GRCh38]
Chr17:47590272 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.822-10C>G single nucleotide variant not provided [RCV000880907] Chr17:49511882 [GRCh38]
Chr17:47589244 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.879G>A (p.Thr293=) single nucleotide variant not provided [RCV000958726] Chr17:49511949 [GRCh38]
Chr17:47589311 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.395C>T (p.Ser132Leu) single nucleotide variant not provided [RCV000898324] Chr17:49506485 [GRCh38]
Chr17:47583847 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.630C>T (p.Pro210=) single nucleotide variant not provided [RCV000915782] Chr17:49510473 [GRCh38]
Chr17:47587835 [GRCh37]
Chr17:17q21.33
likely benign
NM_002507.4(NGFR):c.568+9G>A single nucleotide variant not provided [RCV000917555] Chr17:49506667 [GRCh38]
Chr17:47584029 [GRCh37]
Chr17:17q21.33
likely benign
NM_002507.4(NGFR):c.1092C>T (p.Gly364=) single nucleotide variant not provided [RCV000912059] Chr17:49512817 [GRCh38]
Chr17:47590179 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.67-4C>T single nucleotide variant not provided [RCV000911694] Chr17:49502059 [GRCh38]
Chr17:47579421 [GRCh37]
Chr17:17q21.33
benign
NM_002507.4(NGFR):c.1089G>A (p.Ala363=) single nucleotide variant not provided [RCV000890110] Chr17:49512814 [GRCh38]
Chr17:47590176 [GRCh37]
Chr17:17q21.33
likely benign
NM_002507.4(NGFR):c.333C>T (p.Tyr111=) single nucleotide variant not provided [RCV000890197] Chr17:49506423 [GRCh38]
Chr17:47583785 [GRCh37]
Chr17:17q21.33
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7809 AgrOrtholog
COSMIC NGFR COSMIC
Ensembl Genes ENSG00000064300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000172229 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000421731 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000172229 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000504201 UniProtKB/Swiss-Prot
GTEx ENSG00000064300 GTEx
HGNC ID HGNC:7809 ENTREZGENE
Human Proteome Map NGFR Human Proteome Map
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot
  TNFR16_TM UniProtKB/Swiss-Prot
  TNFR_16 UniProtKB/Swiss-Prot
  TNFRSF16_N UniProtKB/Swiss-Prot
KEGG Report hsa:4804 UniProtKB/Swiss-Prot
NCBI Gene 4804 ENTREZGENE
OMIM 162010 OMIM
Pfam Death UniProtKB/Swiss-Prot
  TNFR_16_TM UniProtKB/Swiss-Prot
  TNFR_c6 UniProtKB/Swiss-Prot
PharmGKB PA31615 PharmGKB
PRINTS TNFACTORR16 UniProtKB/Swiss-Prot
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
  TNFR_NGFR_1 UniProtKB/Swiss-Prot
  TNFR_NGFR_2 UniProtKB/Swiss-Prot
SMART DEATH UniProtKB/Swiss-Prot
  TNFR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
UniGene Hs.415768 ENTREZGENE
  Hs.681726 ENTREZGENE
UniProt P08138 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R961 UniProtKB/Swiss-Prot
  B4E096 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-16 NGFR  nerve growth factor receptor  NGFR  nerve growth factor receptor  Symbol and/or name change 5135510 APPROVED
2011-07-27 NGFR  nerve growth factor receptor  NGFR  nerve growth factor receptor (TNFR superfamily, member 16)  Symbol and/or name change 5135510 APPROVED