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Gene: PDGFRA (platelet derived growth factor receptor alpha) Homo sapiens
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Symbol: PDGFRA
Name: platelet derived growth factor receptor alpha
Description: Exhibits several functions, including growth factor binding activity; platelet-derived growth factor receptor binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphorylation; and protein phosphorylation. Localizes to several cellular components, including the cell junction; integral component of plasma membrane; and nucleoplasm. Implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Biomarker of several diseases, including craniopharyngioma; infratentorial cancer (multiple); male reproductive organ cancer (multiple); renal cell carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha platelet-derived growth factor receptor; alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140A; CD140a antigen; GAS9; MGC74795; PDGF-R-alpha; PDGFR-2; PDGFR-alpha; PDGFR2; PDGFRA/BCR fusion; platelet-derived growth factor alpha receptor; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38454,229,127 - 54,298,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37455,095,264 - 55,164,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36454,790,204 - 54,859,169 (+)NCBINCBI36hg18NCBI36
Build 34454,936,129 - 55,005,339NCBI
Celera452,596,023 - 52,665,170 (+)NCBI
Cytogenetic Map4q12NCBI
HuRef451,043,324 - 51,112,555 (+)NCBIHuRef
CHM1_1455,130,846 - 55,199,987 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Sequence

Nucleotide Sequences
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