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Gene: E2F1 (E2F transcription factor 1) Homo sapiens
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Symbol: E2F1
Name: E2F transcription factor 1
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; proximal promoter sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of fibroblast proliferation; and regulation of RNA metabolic process. Localizes to the centrosome and nucleus. Implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Biomarker of several diseases, including chronic myeloid leukemia; lung cancer (multiple); malignant glioma (multiple); neurodegenerative disease (multiple); and viral encephalitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E2F-1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; transcription factor E2F1
Orthologs:
Mus musculus (house mouse) : E2f1 (E2F transcription factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : E2f1 (E2F transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372032,263,292 - 32,274,210 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBINCBI36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBI
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on E2F1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730923
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.