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Gene: E2f1 (E2F transcription factor 1) Mus musculus
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Symbol: E2f1
Name: E2F transcription factor 1
Description: Exhibits DNA-binding transcription factor activity; transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including anoikis; lens fiber cell apoptotic process; and negative regulation of fat cell differentiation. Localizes to cytoplasm; nuclear chromatin; and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E2F-1; KIAA4009; mKIAA4009; Tg(Wnt1-cre)2Sor; transcription factor E2F1
Orthologs:
Homo sapiens (human) : E2F1 (E2F transcription factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : E2f1 (E2F transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
Chlorocebus sabaeus (African green monkey) : E2F1 (E2F transcription factor 1)
Heterocephalus glaber (naked mole-rat) : E2f1 (E2F transcription factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)EnsemblGRCm38mm10GRCm38
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIGRCm37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBImm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on E2f1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730924
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.