Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: E2f1 (E2F transcription factor 1) Mus musculus
Symbol: E2f1
Name: E2F transcription factor 1
Description: Exhibits DNA-binding transcription factor activity; transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including anoikis; lens fiber cell apoptotic process; and negative regulation of fat cell differentiation. Localizes to cytoplasm; nuclear chromatin; and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E2F-1; KIAA4009; mKIAA4009; Tg(Wnt1-cre)2Sor; transcription factor E2F1
Homo sapiens (human) : E2F1 (E2F transcription factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : E2f1 (E2F transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
Chlorocebus sabaeus (African green monkey) : E2F1 (E2F transcription factor 1)
Heterocephalus glaber (naked mole-rat) : E2f1 (E2F transcription factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)EnsemblGRCm38mm10GRCm38
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIGRCm37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBImm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on E2f1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730924
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.