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Gene: BMP15 (bone morphogenetic protein 15) Homo sapiens
Symbol: BMP15
Name: bone morphogenetic protein 15
Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-15; GDF-9B; GDF9B; growth/differentiation factor 9B; ODG2; POF4
Mus musculus (house mouse) : Bmp15 (bone morphogenetic protein 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bmp15 (bone morphogenetic protein 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmp15 (bone morphogenetic protein 15)
Pan paniscus (bonobo/pygmy chimpanzee) : BMP15 (bone morphogenetic protein 15)
Canis lupus familiaris (dog) : BMP15 (bone morphogenetic protein 15)
Sus scrofa (pig) : BMP15 (bone morphogenetic protein 15)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X50,910,735 - 50,916,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X50,653,735 - 50,659,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X50,670,524 - 50,676,347 (+)NCBINCBI36hg18NCBI36
Build 34X50,486,819 - 50,492,643NCBI
CeleraX54,697,190 - 54,703,096 (+)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX48,097,311 - 48,103,406 (+)NCBIHuRef
CHM1_1X50,733,338 - 50,739,244 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BMP15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730933
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.