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Gene: BMP15 (bone morphogenetic protein 15) Homo sapiens
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Symbol: BMP15
Name: bone morphogenetic protein 15
Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-15; GDF-9B; GDF9B; growth/differentiation factor 9B; ODG2; POF4
Orthologs:
Mus musculus (house mouse) : Bmp15 (bone morphogenetic protein 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bmp15 (bone morphogenetic protein 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmp15 (bone morphogenetic protein 15)
Pan paniscus (bonobo/pygmy chimpanzee) : BMP15 (bone morphogenetic protein 15)
Canis lupus familiaris (dog) : BMP15 (bone morphogenetic protein 15)
Sus scrofa (pig) : BMP15 (bone morphogenetic protein 15)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X50,910,735 - 50,916,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X50,653,735 - 50,659,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X50,670,524 - 50,676,347 (+)NCBINCBI36hg18NCBI36
Build 34X50,486,819 - 50,492,643NCBI
CeleraX54,697,190 - 54,703,096 (+)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX48,097,311 - 48,103,406 (+)NCBIHuRef
CHM1_1X50,733,338 - 50,739,244 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
 
More on BMP15
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730933
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.