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Gene: HIF1A (hypoxia inducible factor 1 subunit alpha) Homo sapiens
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Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Hsp90 protein binding activity; and enzyme binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including oxygen homeostasis; positive regulation of biosynthetic process; and regulation of gene expression. Localizes to the cytosol and nucleus. Implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Biomarker of several diseases, including arthritis (multiple); invasive ductal carcinoma; kidney cancer (multiple); morbid obesity; and mycosis fungoides.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARNT interacting protein; ARNT-interacting protein; basic-helix-loop-helix-PAS protein MOP1; bHLHe78; class E basic helix-loop-helix protein 78; HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8
Orthologs:
Mus musculus (house mouse) : Hif1a (hypoxia inducible factor 1, alpha subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hif1a (hypoxia inducible factor 1 subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hif1a (hypoxia inducible factor 1 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HIF1A (hypoxia inducible factor 1 subunit alpha)
Canis lupus familiaris (dog) : HIF1A (hypoxia inducible factor 1 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hif1a (hypoxia inducible factor 1 subunit alpha)
Sus scrofa (pig) : HIF1A (hypoxia inducible factor 1 subunit alpha)
more info ...
Related Pseudogenes: HIF1AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381461,695,513 - 61,748,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371462,162,118 - 62,214,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361461,231,992 - 61,284,729 (+)NCBINCBI36hg18NCBI36
Build 341461,231,991 - 61,284,729NCBI
Celera1442,212,391 - 42,265,247 (+)NCBI
Cytogenetic Map14q23.2NCBI
HuRef1442,326,005 - 42,378,869 (+)NCBIHuRef
CHM1_11462,101,569 - 62,154,420 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated