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Gene: PRKN (parkin RBR E3 ubiquitin protein ligase) Homo sapiens
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
CRRD ID: 730938
Description: Exhibits several functions, including cytoskeletal protein binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including negative regulation of cell communication; protein ubiquitination; and regulation of organelle organization. Localizes to several cellular components, including Parkin-FBXW7-Cul1 ubiquitin ligase complex; aggresome; and nuclear speck. Colocalizes with mitochondrion-derived vesicle. Implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Biomarker of Alzheimer's disease; Lewy body dementia; Parkinson's disease; cervical cancer; and multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AR-JP; E3 ubiquitin ligase; E3 ubiquitin-protein ligase parkin; LPRS2; PARK2; parkin 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson disease protein 2; parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin); PDJ
Mus musculus (house mouse) : Prkn (parkin RBR E3 ubiquitin protein ligase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkn (parkin RBR E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Sus scrofa (pig) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Chlorocebus sabaeus (African green monkey) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Heterocephalus glaber (naked mole-rat) : Prkn (parkin RBR E3 ubiquitin protein ligase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6161,347,417 - 162,727,771 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6161,347,417 - 162,727,775 (-)EnsemblGRCh38hg38GRCh38
GRCh386161,347,417 - 162,727,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376161,768,590 - 163,148,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,689,661 - 163,068,793 (-)NCBINCBI36hg18NCBI36
Build 346161,740,081 - 163,119,211NCBI
Celera6162,497,923 - 163,878,436 (-)NCBI
Cytogenetic Map6q26NCBI
HuRef6159,224,034 - 160,600,983 (-)NCBIHuRef
CHM1_16162,031,091 - 163,411,071 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences