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Gene: TGFB2 (transforming growth factor beta 2) Homo sapiens
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Symbol: TGFB2
Name: transforming growth factor beta 2
Description: Exhibits amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of macromolecule metabolic process. Localizes to the collagen-containing extracellular matrix and extracellular space. Implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Biomarker of colon carcinoma; colorectal cancer; and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BSC-1 cell growth inhibitor; cetermin; G-TSF; glioblastoma-derived T-cell suppressor factor; LDS4; MGC116892; polyergin; prepro-transforming growth factor beta-2; TGF-beta-2; TGF-beta2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein; transforming growth factor, beta 2
Orthologs:
Mus musculus (house mouse) : Tgfb2 (transforming growth factor, beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgfb2 (transforming growth factor, beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb2 (transforming growth factor beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB2 (transforming growth factor beta 2)
Canis lupus familiaris (dog) : TGFB2 (transforming growth factor beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb2 (transforming growth factor beta 2)
Sus scrofa (pig) : TGFB2 (transforming growth factor beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,345,284 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371218,518,676 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBI
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TGFB2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730953
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.