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Gene: PDE2A (phosphodiesterase 2A) Homo sapiens
Symbol: PDE2A
Name: phosphodiesterase 2A
Description: Exhibits several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; cyclic nucleotide binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Localizes to several cellular components, including the cytosol; mitochondrial membrane; and perinuclear region of cytoplasm; PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 8-bromo-3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP-stimulated phosphodiesterase; PDE2A1; PED2A4; phosphodiesterase 2A, cGMP-stimulated
Mus musculus (house mouse) : Pde2a (phosphodiesterase 2A, cGMP-stimulated)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde2a (phosphodiesterase 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde2a (phosphodiesterase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE2A (phosphodiesterase 2A)
Canis lupus familiaris (dog) : PDE2A (phosphodiesterase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde2a (phosphodiesterase 2A)
Sus scrofa (pig) : PDE2A (phosphodiesterase 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381172,576,140 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,287,184 - 72,385,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDE2A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730957
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.