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Gene: GRM5 (glutamate metabotropic receptor 5) Homo sapiens
Symbol: GRM5
Name: glutamate metabotropic receptor 5
Description: Exhibits G protein-coupled receptor activity; glutamate receptor activity; and identical protein binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and regulation of cellular protein metabolic process. Localizes to the integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glutamate receptor, metabotropic 5; GPRC1E; GRM5 variant 9; metabotropic glutamate receptor 5; metabotropic glutamate receptor 5 variant F; metabotropic glutamate receptor 5 variant G; metabotropic glutamate receptor 5 variant H; mGlu5; MGLUR5; PPP1R86
Mus musculus (house mouse) : Grm5 (glutamate receptor, metabotropic 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grm5 (glutamate metabotropic receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm5 (glutamate metabotropic receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM5 (glutamate metabotropic receptor 5)
Canis lupus familiaris (dog) : GRM5 (glutamate metabotropic receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm5 (glutamate metabotropic receptor 5)
Sus scrofa (pig) : GRM5 (glutamate metabotropic receptor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381188,504,576 - 89,065,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371188,237,256 - 88,796,846 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,880,626 - 88,420,838 (-)NCBINCBI36hg18NCBI36
Build 341187,880,625 - 88,420,838NCBI
Celera1185,835,181 - 86,394,276 (+)NCBI
Cytogenetic Map11q14.2-q14.3NCBI
HuRef1184,476,702 - 85,036,122 (-)NCBIHuRef
CHM1_11188,120,759 - 88,679,848 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRM5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730960
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.