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Gene: DNM2 (dynamin 2) Homo sapiens
Symbol: DNM2
Name: dynamin 2
Description: Exhibits SH3 domain binding activity. Involved in negative regulation of membrane tubulation; receptor internalization; and transferrin transport. Localizes to several cellular components, including the Golgi apparatus; microtubule; and postsynaptic membrane. Predicted to colocalize with the growth cone. Implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; dynamin II; dynamin-2; DYNII; LCCS5
Mus musculus (house mouse) : Dnm2 (dynamin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnm2 (dynamin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm2 (dynamin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM2 (dynamin 2)
Canis lupus familiaris (dog) : DNM2 (dynamin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm2 (dynamin 2)
Sus scrofa (pig) : DNM2 (dynamin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,718,053 - 10,831,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,828,729 - 10,944,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DNM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730970
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.