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Gene: DNM2 (dynamin 2) Homo sapiens
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Symbol: DNM2
Name: dynamin 2
Description: Exhibits SH3 domain binding activity. Involved in negative regulation of membrane tubulation; receptor internalization; and transferrin transport. Localizes to several cellular components, including the Golgi apparatus; microtubule; and postsynaptic membrane. Predicted to colocalize with the growth cone. Implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; dynamin II; dynamin-2; DYNII; LCCS5
Orthologs:
Mus musculus (house mouse) : Dnm2 (dynamin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnm2 (dynamin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm2 (dynamin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM2 (dynamin 2)
Canis lupus familiaris (dog) : DNM2 (dynamin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm2 (dynamin 2)
Sus scrofa (pig) : DNM2 (dynamin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,718,053 - 10,831,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,828,729 - 10,944,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,689,755 - 10,803,579 (+)NCBINCBI36hg18NCBI36
Build 341910,689,754 - 10,803,579NCBI
Celera1910,723,575 - 10,837,431 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,405,937 - 10,520,718 (+)NCBIHuRef
CHM1_11910,829,940 - 10,943,823 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DNM2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730970
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.