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Gene: Srebf2 (sterol regulatory element binding factor 2) Mus musculus
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Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Description: Exhibits DNA-binding transcription factor activity and transcription regulatory region DNA binding activity. Involved in cholesterol homeostasis and positive regulation of pri-miRNA transcription by RNA polymerase II. Localizes to the cytoplasm; membrane; and nucleus. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2); PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381582,147,269 - 82,205,379 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371581,977,699 - 82,035,390 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,974,524 - 82,032,215 (+)NCBImm8
Celera1584,270,919 - 84,328,680 (+)NCBICelera
Cytogenetic Map15 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Srebf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730973
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.