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Gene: AVPR2 (arginine vasopressin receptor 2) Homo sapiens
Symbol: AVPR2
Name: arginine vasopressin receptor 2
Description: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADHR; antidiuretic hormone receptor; AVPR V2; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; renal-type arginine vasopressin receptor; V2R; vasopressin V2 receptor
Mus musculus (house mouse) : Avpr2 (arginine vasopressin receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Avpr2 (arginine vasopressin receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Avpr2 (arginine vasopressin receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AVPR2 (arginine vasopressin receptor 2)
Canis lupus familiaris (dog) : AVPR2 (arginine vasopressin receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Avpr2 (arginine vasopressin receptor 2)
Sus scrofa (pig) : AVPR2 (arginine vasopressin receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X153,902,531 - 153,907,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,167,985 - 153,172,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,823,564 - 152,825,834 (+)NCBINCBI36hg18NCBI36
Build 34X152,691,216 - 152,693,487NCBI
CeleraX153,401,665 - 153,406,333 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,789,000 - 141,824,020 (+)NCBIHuRef
CHM1_1X153,042,396 - 153,047,068 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on AVPR2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730975
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.