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Gene: HSF1 (heat shock transcription factor 1) Homo sapiens
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Symbol: HSF1
Name: heat shock transcription factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and Hsp90 protein binding activity. Involved in several processes, including cellular response to diamide; cellular response to metal ion; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including the kinetochore; microtubule cytoskeleton; and nucleus. Implicated in Huntington's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: heat shock factor protein 1; HSF 1; HSTF 1; HSTF1
Orthologs:
Mus musculus (house mouse) : Hsf1 (heat shock factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsf1 (heat shock transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsf1 (heat shock transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSF1 (heat shock transcription factor 1)
Canis lupus familiaris (dog) : HSF1 (heat shock transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsf1 (heat shock transcription factor 1)
Sus scrofa (pig) : HSF1 (heat shock transcription factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,291,603 - 144,314,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,515,270 - 145,538,385 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,486,078 - 145,509,193 (+)NCBINCBI36hg18NCBI36
Build 348145,486,090 - 145,509,187NCBI
Celera8141,707,360 - 141,713,153 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,629,839 - 140,652,904 (+)NCBIHuRef
CHM1_18145,553,452 - 145,576,661 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HSF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 730995
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.