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Gene: CASP3 (caspase 3) Homo sapiens
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Symbol: CASP3
Name: caspase 3
Description: Exhibits cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in several processes, including cellular response to staurosporine; neurotrophin TRK receptor signaling pathway; and positive regulation of amyloid-beta formation. Localizes to the cytosol and nucleus. Implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); neurodegenerative disease (multiple); reproductive organ cancer (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP-32; CPP32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; SCA-1; SREBP cleavage activity 1; Yama
Orthologs:
Mus musculus (house mouse) : Casp3 (caspase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp3 (caspase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp3 (caspase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP3 (caspase 3)
Canis lupus familiaris (dog) : CASP3 (caspase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp3 (caspase 3)
Sus scrofa (pig) : CASP3 (caspase 3)
more info ...
Related Pseudogenes: CASP3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,627,696 - 184,649,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374185,548,850 - 185,570,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBINCBI36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model