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Gene: CCN2 (cellular communication network factor 2) Homo sapiens
Symbol: CCN2
Name: cellular communication network factor 2
Description: Exhibits protein C-terminus binding activity. Involved in positive regulation of MAPK cascade; positive regulation of cell differentiation; and positive regulation of stress fiber assembly. Colocalizes with collagen-containing extracellular matrix. Biomarker of ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCN family member 2; connective tissue growth factor; CTGF; HCS24; hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; IGFBP8; insulin-like growth factor-binding protein 8; MGC102839; NOV2
Mus musculus (house mouse) : Ccn2 (cellular communication network factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccn2 (cellular communication network factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccn2 (cellular communication network factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CCN2 (cellular communication network factor 2)
Canis lupus familiaris (dog) : CCN2 (cellular communication network factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccn2 (cellular communication network factor 2)
Sus scrofa (pig) : CCN2 (cellular communication network factor 2)
Chlorocebus sabaeus (African green monkey) : CCN2 (cellular communication network factor 2)
Heterocephalus glaber (naked mole-rat) : Ccn2 (cellular communication network factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6131,948,176 - 131,951,372 (-)EnsemblGRCh38hg38GRCh38
GRCh386131,948,176 - 131,951,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376132,269,316 - 132,272,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,311,009 - 132,314,211 (-)NCBINCBI36hg18NCBI36
Build 346132,311,017 - 132,314,147NCBI
Celera6133,016,448 - 133,019,647 (-)NCBI
Cytogenetic Map6q23.2NCBI
HuRef6129,844,775 - 129,847,974 (-)NCBIHuRef
CHM1_16132,533,071 - 132,536,270 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CCN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731013
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.